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Obese Zucker rats treated with AOD-9604 at 500 mcg/kg/day for 19 days showed a statistically significant reduction in body fat compared to vehicle-treated controls
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Numerous agents targeting the JAKs-STAT1/5, JAKs-STAT3/6, TLR4-NF-κB, MAPK, PI3K-AKT-mTOR, AMPK-PPAR and Nrf2-HO-1 pathways have been shown to induce M2 macrophage polarization and/or inhibit M1 macrophage polarization (178, 179), paving the way for the development of novel therapeutic strategies targeting macrophage functions specific to CKD and associated pathologies
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