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Reported or clinically relevant reactions may include: Hypersensitivity: Rash, pruritus, urticaria, facial swelling, dyspnea, hypotension, or anaphylaxis Injection site: Pain, tenderness, erythema, swelling, or local irritation Gastrointestinal: Nausea, abdominal discomfort, or transient diarrhea Neurologic: Headache, dizziness, or lightheadedness General: Flushing, malaise, or a sensation of generalized swelling Metabolic: Hypokalemia during rapid correction of severe megaloblastic anemia Respiratory difficulty, facial or airway swelling, hypotension, or other evidence of a serious reaction requires immediate discontinuation and medical evaluation [1,3]