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It is also possible that our sample size was too small to detect minor genotype-related differences, or that in the context of severe deficiency, everyone is at risk, regardless of genetic background.Notably, the lack of a significant effect of the MTHFR C677T polymorphism on homocysteine levels suggests that severe vitamin deficiencies may override genetic predisposition in this pediatric cohort

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The inflammation may be associated with a degenerative tear of the TFC or with synovitis of the complex