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Toner, at Mass General, said scaling up from a rat to a larger animal presents a major hurdle
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The antidromic release of neuropeptides from nociceptors in the airways causes vasodilatation and oedema, which are associated with nasal obstruction in the upper airways and bronchoconstriction in the lower airways, as well as plasma protein exudation, mucus secretion and inflammatory cell recruitment
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