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The most common CBS mutation substitutes the amino acid threonine for the amino acid isoleucine at the position of 278 in the enzyme, known to the scientific world as Ile278Thr or I278T
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In the hypoxic niche, GSCs are induced through the mechanisms of HIFs
![Synthesis of Oligonucleotides Containing the Ethylene Dibromide-Derived DNA Adducts S-[2-(N7-Guanyl)ethyl]glutathione, S-[2-(N2-Guanyl)ethyl]glutathione, and S-[2-(O6-Guanyl)ethyl]glutathione at a Single Site](https://pubs.acs.org/cms/10.1021/tx9701081/asset/images/large/tx9701081f00001.jpeg)
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