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Since MCAS does not always show up on standard allergy or autoimmune panels, it is frequently misdiagnosed as seasonal or food allergies, IBS or other GI disorders, panic attacks, generalized anxiety, and even fibromyalgia

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Interestingly, an electrophilic molecule, 15-deoxy-∆12,14)-prostaglandin J2, is produced by convoluted blood flow with shear stress and activates Nrf2 in endothelial cells [23]