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This deficiency can lead to various complications, including nerve damage in the extremities, dysfunction of the autonomic nervous system related to the heart, symptoms affecting the brain and nerves, or blood-related disorders
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For example, several studies support a causal relationship between augmented NNMT activity in cancer cells and tumor proliferation/progression in a variety of cancerous states with potential implications for NNMT as a biomarker for cancer prognosis and a relevant target for anti-cancer therapeutic development
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