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In terms of the occurrence of Hhcy in patients with β-TM based on their MTHFR genotypes, the data show a significant and clear connection between Hhcy and possession of the MTHFR TT genotype, with all patients with the TT genotype (100%) being assessed hyperhomocystinemic (≥15 mol/l) compared to those with CT (40%) or CC genotypes (29%) P (Fig