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For example, the K64Q mutation displays the highest affinity for PI(4,5)P 2 with a preference for particular acyl chains, the R92P mutation results in the relatively non-specific binding of various PIP isoforms, and the K194A mutation exhibits a binding preference for PI(3,4,5)P 3 over other PIPs (Qiao et al., 2020)

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Chem Biol Interact