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In studies of neuronal cell cultures, berberine has been shown to maintain mitochondrial membrane potential, reduce excitotoxic glutamate release, and modulate key stress-response kinases, thereby preserving neuronal viability across various pathological conditions [26]

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Flavonoids, for instance, penetrate the blood-brain barrier and exert neuroprotective effects by enhancing synaptic plasticity, decreasing neuroinflammation, and stimulating neurogenesis [10]