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Preclinical research in murine senescence models has examined FOXO4-DRI for its capacity to reduce senescent cell burden, with observed improvements in physical function, coat density, and renal histology endpoints in aged subjects

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Acknowledgements This work was supported by the UKRI Biotechnology and Biological Sciences Research Council (BBSRC) Norwich Research Park Biosciences Doctoral Training Partnership grant number BB/M011216/1, the BBSRC Institute Strategic Programme (ISP) Food Innovation and Health BB/R012512/1 and its constituent project BBS/E/F/000PR10347 (Theme 4, Regulation of Metabolic Homeostasis)