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Size:10mg
Indeed, the main targets for mitochondria-generated ROS are mitochondrial permeability transition pore (MPTP), poly (ADP-ribose) polymerase (PARP), and mtDNA ( Other oxidant sources arise from NADPH oxidase, present in astrocytes, microglia and neurons, while NOS inhibition has shown neuroprotective effects ( In the pathogenesis of neurodegeneration, many processes are included, such as protein misfolding and aggregation, abnormal kinase-signaling pathways, neuronal calcium dysregulation, and even impaired synaptic transmission (Takalo et al., 2013)