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It has traditionally been used to treat a variety of health issues, including digestive, respiratory, cardioprotective, antidiabetic, anti-inflammatory, and antiviral effects, immune system function, nephroprotective, and hepatoprotective properties

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It will then systematically discuss the upstream regulatory mechanisms of GPX4 in the context of OA, including the System Xc − and nuclear factor erythroid 2-related factor 2(Nrf2) signaling pathways, as well as its downstream biological effects, such as impacts on chondrocyte survival, inflammatory responses, and ECM metabolism