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Accessory cells of the microenvironment protect multiple myeloma from T-cell cytotoxicity through cell adhesion-mediated immune resistance

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Its core physiological function is to catalyze the methylation of nicotinamide (NAM, a key precursor for NAD+ synthesis) with S‑adenosylmethionine (SAM) to produce 1‑methylnicotinamide (1‑MNA)

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