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The researchers commented, “The findings from the present study suggested that Tβ4 may promote angiogenesis [...] via regulation of Notch/NF-κB pathways.” BPC-157 & TB-500 Peptides and Growth Hormones, Synergism Growth hormone may be a critical mediator in the synergism between BPC-157 and TB-500 when observed in the context of wound healing, as both molecules appear to interact with the growth hormone during the healing process