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Researchers therefore investigate whether NNMT inhibition may influence intracellular NAD+ metabolism

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When cagrilintide is combined with GLP-1 receptor agonists like semaglutide (both of which slow gastric emptying and cause GI effects), there is potential for additive gastrointestinal adverse events, and indeed, combination therapy trials have reported somewhat higher rates of nausea and vomiting compared to either agent alone