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The one study which did include reproductive-age women was limited to European adolescents who adhered to a specific diet plan (one group consumed a macrobiotic diet for up to 6 years followed by a vegetarian/omnivorous diet while the other group ate an omnivorous diet throughout their life)
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As radial chromosomes in HR-defective cells arise from illegitimate rejoining of DSBs by NHEJ 32 , these observations implied that NHEJ is not affected by loss of PDS5B
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