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Some of the small-molecule inhibitors have been studied in a phase II or III clinical trial, including 2-methoxyestradiol (2ME2), tanespimycin, vorinostat, PT2385, PT2977, and CRLX101 13,121

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Lowering uric acid in the bloodstream After a first gout attack, your doctor will discuss with you whether you may benefit from medications to help lower the level of uric acid in your bloodstream

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