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166,167 The pathophysiology of diabetic mononeuropathy includes ischemic mechanisms, such as the occlusion of the vasa nervorum leading to nerve infarction, metabolic factors, including hyperglycemia-induced oxidative stress, and the formation of advanced glycation end products, contributing to nerve damage

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The enzyme glutamine-PRPP amidotransferase catalyzes this reaction

especially for individuals with underlying health conditions or who are pregnant or breastfeeding.