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One study found that 8 weeks of resistance training significantly activated PERK/ATF4 and IRE1/XBP1 UPR pathways in peripheral blood mononuclear cells of older adults, while upregulating PGC-1α and the mitochondrial fusion protein Mfn1, without altering levels of mitophagy markers PINK1/Parkin or Bnip3/Nix ( Overall, the principal contribution of resistance training lies in optimizing myocellular structural integrity and improving local proteostasis and redox environment

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(2020) Nucleotides cytidine and uridine associated with vitamin B12 vs B-complex vitamins in the treatment of low back pain: the NUBES study