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NBDHEX acts as a mechanism-based inhibitor of GSTP1-1, where it is first recognized as a substrate and makes a spontaneous intermediate σ- complex with GSH, which binds very tightly to the enzyme and results in the loss of both the GSH-conjugating activity as well as the ability to form complexes with partner proteins JNK1 and TRAF2 [62,95,97]
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Session:Free Consultation - South Woodford (Refundable Deposit)
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