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In addition, patient stratification based on DDRGK1 expression and IDH status may help enrich for responsive cohorts, whereas adaptive trial designs incorporating on-treatment biopsies will be important to monitor and counter emerging resistance
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Intriguingly, correlation analyses linked microbiota changes to alterations in stress hormones, neurotransmitters, inflammatory markers and anxiety-like behaviors, suggesting a gut–brain contribution to the observed behavioral manifestations in anxiety pathology (Jia et al., 2024
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