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The NIH found no difference, thus far, between CD4/CD8 ratios or NK cell frequency in ME/CFS and healthy controls, but check out what happened when they examined B-cell frequency: normal in the blood but very low – so low that Walitt called it a “bottoming out” – in the spinal fluid

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Modulation of the Nitric Oxide (NO) System Nitric Oxide (NO) is a highly versatile signaling molecule involved in a vast array of physiological processes, including vasodilation (the widening of blood vessels), neurotransmission, and immune response