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Despite the lack of a definitive diagnosis through an exercise provocation test being a limitation, the diagnosis was based on the patient's history and positive specific IgE antibodies to component testing to tri a 19 (omega-5 gliadin) wheat

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As one 2026 review put it, the original composition-of-matter patents "have likely expired… reducing the commercial exclusivity that typically incentivizes industry-sponsored Phase II and III development" [13]