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The votes are advisory and non-binding — the FDA makes the final call, and its own career scientists had recommended against all seven in their June 30 briefing
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Heme enters CydDC via the membrane and rotates by 180° To map possible routes of heme entry, we carried out multiple atomistic MD simulations, focusing on the behavior of heme near lipid bilayer surfaces (70% palmitoyloleoyl phosphatidylethanolamine (POPE), 25% palmitoyloleoyl phosphatidylglycerol (POPG) and 5% cardiolipin) and the substrate-binding pocket (Fig
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