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On the other hand, the multi-receptor agonists currently in development (tirzepatide targeting GIP/GLP-1, retatrutide targeting GIP/GLP-1/glucagon, survodutide targeting glucagon/GLP-1) have shown that engaging multiple incretin and related pathways can produce greater weight loss and broader metabolic benefits than GLP-1 agonism alone

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These can include nausea, vomiting, diarrhea, constipation, abdominal discomfort, reflux, and reduced appetite