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Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

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In addition to genetics, other hyperuricaemia/gout risk factors include: 1, 5, 6 Older age Male sex Obesity Cardio-metabolic co-morbidities, particularly CKD, hypertension and hyperlipidaemia Use of medicines that influence urate production, reabsorption or excretion, e.g