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Schematically: Enzyme-His-phosphate + 3-PG ⇄ Enzyme-His + 2,3-BPG Enzyme-His + 2,3-BPG ⇄ Enzyme-His-phosphate + 2-PG It is important to note that the phosphoryl group in 2-phosphoglycerate is not the same as the one originally present in 3-phosphoglycerate

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