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elevated levels of MLCK and phosphorylated MLC (pMLC) are associated with stress-induced intestinal permeability dysfunction [15,17]

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In the liver, feeding-induced FXR activation elevates SHP expression, which forms a complex with CREB to recruit lysine-specific demethylase 1 (LSD1) to the promoters of ATGs such as Tfeb, Ulk1 , and Atg7