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Acute Opioid Withdrawal: Identification and Treatment Strategies

Xu Wang, Arturo Anadón and María-Aránzazu Martinez: Supervision, Visualization, Writing—Review & Editing, Project administration, Funding acquisition

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First, mechanistic studies should integrate single-cell transcriptomics and spatial metabolomics to map cell-type-specific ferroptosis pathways in hippocampal and cortical neurons and microglia, with particular focus on the link between NCOA4-mediated ferritinophagy and Aβ clearance, thereby building a dynamic model connecting iron dysregulation, proteotoxic stress, and cell death