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A couple of subsequent recent multicentre double-blinded randomised trials of a combination of vitamin C and E [130, 131] also found that supplementation did not reduce the rate of preeclampsia or gestational hypertension and, like the Vitamins In Preeclampsia trial in 2006 [132], increased the risk of fetal loss or perinatal death and preterm prelabour rupture of membranes

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