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Finally, depletion of HDAC2, corresponding to HDAC2 , identified in a targeted CRISPR screen, led to decreased IFN-γ-dependent PD-L1 expression with lower phosphorylation of proteins JAK1/2 and STAT 78182183

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Similarly, increased GPX4 ubiquitination by DMOCPTL, a natural product parthenolide derivative, induces ferroptosis and apoptosis in human triple-negative breast cancer cells [64]