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J Neurochem (1999) 73(3):1309–17.10.1046/j.1471-4159.1999.0731309.x 12 PerierCTieuKGuéganCCaspersenCJackson-LewisVCarelliVet alComplex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage

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ITPP works by reducing hemoglobin’s oxygen-binding affinity, increasing the oxygen-release capacity of red blood cells (156)