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doi: 10.1111/j.1471-4159.2006.03885.x 28 YamaguchiHMatsumuraTSugawaHNiimiNSangoKNagaiR

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Introduction Dry eye disease (DED), a multifactorial and complex disease of the tear film, eyelids, lacrimal glands, and a variety of ocular surface tissues, is characterized by loss of tear film homeostasis and accompanied by ocular symptoms [1]