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Poster Session II - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.01 - PATHOPHYSIOLOGY OF STROKE / TRANSLATIONAL MEDICINE P1083 - ESOC25-2127 THROMBOEMBOLIC STROKE ALTERS CLAUDIN-5 ISOFORM EXPRESSION CORRELATING TO INCREASED CEREBRAL INFARCT AND EDEMA AS WELL AS DECREASED NEUROLOGICAL FUNCTION Trevor Wendt 1 , Kajsa Arkelius 1 , Henrik Andersson 1 , Rayna Gonzales 2 , Saema Ansar 1 1 Lund University, Lund, Sweden, 2 University of Arizona College of Medicine - Phoenix, Phoenix, United States Background and Aims: Claudin-5, coined as the gatekeeper of neurological function, is integral in the maintenance of the blood-brain barrier (BBB)
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Initial Treatment in Combination with Pembrolizumab and Platinum The efficacy of pemetrexed for injection in combination with pembrolizumab and platinum chemotherapy was investigated in Study KEYNOTE-189 (NCT02578680), a randomized, multicenter, double-blind, active-controlled trial conducted in patients with metastatic non-squamous NSCLC, regardless of PD-L1 tumor expression status, who had not previously received systemic therapy for metastatic disease and in whom there were no EGFR or ALK genomic tumor aberrations
