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Frontiers | Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders

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Studies in the 1960s [95,96] demonstrated in vitro, in both aqueous solution and also in human blood samples, that epinephrine binds directly to glutathione and when oxidized to its adrenochrome form, epinephrine can undergo a covalent reaction producing an adduct that involves the glutathione sulfhydryl group