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∼0.5 μM for retigabine) comparable to their EC 50 s for activation of KCNQ channels from heterologous expression studies (0.7 μM for ICA 69673 and 0.4 μM for retigabine, both assayed with KCNQ2/3 heteromeric channels) (Figures 2A,B, 3A, left)
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Coherent with this, an umbrella meta-analysis of 13 meta-analyses of RCTs on the effects of probiotics on cognitive and metabolic function in AD has recently been published (120)
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