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Expression of Human A53T Alpha-Synuclein in the Rat Substantia Nigra Using a Novel AAV1/2 Vector Produces a Rapidly Evolving Pathology With Protein Aggregation, Dystrophic Neurite Architecture and Nigrostriatal Degeneration With Potential to Model the Pathology of Parkinson’s Disease

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However, this effect was reversed by treatment with an AKT activator or the selective antagonist 4-PPDOT