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Since the early nineties of the last century, HIV-1 is known to damage the DNA of its host and activate genes involved in the DNA damage response (DDR) (294, 311–314), and HIV-1 is also well known for its ability to fuse its host cells and thereby reach 4-5 times higher reproduction rates (304, 315)
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Conjugation of the nonsignaling COOH-terminus of this modified PTHrP to a linear peptide of 20 D-glutamic acid residues (D-Glu 20 ) allowed for retention of PTHrP signaling activity following its adsorption to exposed hydroxyapatite
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