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The search included articles published between 2010 and 2025, using keywords: “Parkinson’s disease,” “ α -synuclein,” “dopaminergic degeneration,” “ferroptosis,” “deep brain stimulation,” “stem cell therapy,” and “AI in PD diagnosis.” Results The review highlights a multifactorial etiology involving α -synuclein pathology, oxidative stress, mitochondrial dysfunction, genetic mutations (SNCA, LRRK2, VPS35), environmental toxins, and gut dysbiosis

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