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Chandra J, Pahler J, Niemer I, Andreeff M , Keating M, McConkey DJ

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Mechanistically, it was revealed that glutamine uptake effectively increased the concentration of tumor glutamine and its downstream metabolite α-KG, which drove hypomethylation of H3K4me3 via JmjC-containing KDMs, resulting in the downregulation of epigenetically activated oncogenic pathways [89]