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In search for the mechanism of reduced NRF2 activity in ATM null cells, we confirmed the role of BRCA1 in the regulation of the NRF2 antioxidant response
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To characterize the genetic variation of ADME genes, nonsynonymous SNVs (nsSNVs) with functional abnormalities from the Jakun genome were annotated against the publicly available PharmGKB dataset to investigate their possible associations with drug transport, metabolism and drug targets 24
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