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SIRT1 deacetylates and activates key transcription factors such as FOXO and PGC-1α that promote neuronal survival and mitochondrial biogenesis, while SIRT3 enhances mitochondrial function and reduces oxidative stress in neurons

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NMN is synthesized in the body via two pathways, the Salvage and Preiss-Handler pathways, with the former synthesizing NMN from vitamin B3

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