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A newly developed “dormancy-activation” control pharmacologically modulates the mammalian target of rapamycin pathway to tune the NSC cell cycle, increasing therapeutic efficacy by ~3.2-fold [147]

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Meta-analyses show that mid-life depression is consistently associated with increased levels of inflammatory markers in blood, including C-reactive protein (CRP), Interleukin-6 (IL-6), Interleukin-1 beta (IL-1β), and Tumor necrosis factor-alpha (TNF-α), particularly during depressive episodes [264, 265]