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Strictly, then, it was halted for futility rather than having formally missed its endpoint — but either way no zonulin-directed therapy is approved, and a good deal of secondary writing still describes larazotide as though approval were imminent

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To enhance the cell permeability of RT, we converted the carboxylic acid groups to acetoxymethyl (AM) esters, which are readily hydrolysed by esterases to regenerate RT inside cells