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declares research grants from Incyte, Albireo-Ipsen, Servier, Taiho and Cymabay-Gilead, personal fees for lectures from Servier, AstraZeneca, Eisai, Advanz and Ipsen, and consulting fees for Ipsen, Cymabay, AstraZeneca, Servier, Rubió Metabolomics and Jazz Pharmaceuticals

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The authors emphasize the necessity of testing such combinatorial interventions in naturally aged rodents to better capture the complexity of late-life aging phenotypes, as opposed to relying solely on progeroid or accelerated models, since interventions tested in such models are at risk of disproportionately addressing a single cause of aging phenotype (Lewis and de Grey, 2024)

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