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Already in 1971 [i.e., 13 years after the first crystal structure of a protein, myoglobin, was solved in 1958 (Kendrew et al., 1958), and when only seven protein crystal structures were known (Minor et al., 2016)], a study on the X-ray crystal structure of staphylococcus nuclease first used the term “disordered” to describe two regions of missing electron density (Arnone et al., 1971)

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Chlorpyrifos markedly decreased the testicular sialic acid and glycogen levels, too, while increasing the level of cholesterol [31]