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However, the more pronounced differences in astrocyte reactivity, microglial activation, oxidative stress, tissue swelling and demyelination within the cuprizone pellet group compared to their controls at 3 weeks, despite no significant weight loss, suggest that weight loss may not be a reliable proxy of the extent of demyelinating disease

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Structural focus: As a 16-amino acid peptide, this research compound is significantly smaller and more structurally defined than the 191-amino acid full GH molecule, making it a more tractable research tool for studying specific receptor-ligand interactions and downstream signalling mechanisms in controlled laboratory settings