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doi: 10.1093/hmg/ddw045

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The neuroprotective effects of the ketogenic diet are closely linked to its induction of metabolic remodeling and protein modification: by increasing β-hydroxybutyrate levels, it specifically promotes β-hydroxybutyrylation of key tricarboxylic acid (TCA) cycle enzymes (such as citrate synthase [CS] and succinate-CoA ligase subunit alpha [SUCLG1]), enhancing enzymatic activity and ATP production to improve neuronal energy metabolism