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In dogs with CIE and suboptimal cobalamin status, cobalamin is recommended to be given at a dose of 50 μg/kg SC every 7 days or 50 μg/kg PO q24h.28, 33 Current consensus is that oversupplementation with cobalamin or cobalamin toxicity does not occur

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Common Side Effects for Both Compounds: The high prevalence of gastrointestinal adverse events with each compound individually suggests that combining them could potentially result in: More severe nausea and vomiting episodes Higher discontinuation rates Reduced treatment adherence Potential nutritional deficiencies from excessive appetite suppression Dehydration risks from combined GI effects Health and wellness professionals must understand these risks when evaluating any experimental protocols involving cagrilintide alongside other metabolic peptides